Early rapid eye movement sleep behavior disorder predicts incident cognitive impairment in Parkinson's disease across ages

Lauren E Kenney; Adrianna M Ratajska; Francesca V Lopez; Michael Marsiske; Dawn Bowers

doi:10.1016/j.parkreldis.2023.105392

Early rapid eye movement sleep behavior disorder predicts incident cognitive impairment in Parkinson's disease across ages

Parkinsonism Relat Disord. 2023 May:110:105392. doi: 10.1016/j.parkreldis.2023.105392. Epub 2023 Apr 1.

Authors

Lauren E Kenney¹, Adrianna M Ratajska², Francesca V Lopez³, Michael Marsiske⁴, Dawn Bowers⁵

Affiliations

¹ Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, 32608, USA. Electronic address: [email protected].
² Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, 32608, USA. Electronic address: [email protected].
³ Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, 32608, USA. Electronic address: [email protected].
⁴ Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA. Electronic address: [email protected].
⁵ Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, 32608, USA. Electronic address: [email protected].

Abstract

This study demonstrated possible rapid eye movement sleep behavior disorder (RBD)'s relationship to longitudinal, incident cognitive impairment in the Parkinson's Progression Markers Initiative (PPMI) database. Age did not moderate this relationship, suggesting that RBD serves as a cognitive risk factor across individuals of all ages with recently diagnosed Parkinson's disease.

Keywords: Cognition; Parkinson's disease; Rapid eye movement sleep behavior disorder; Risk factors; Survival analyses.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Cognitive Dysfunction* / diagnosis
Cognitive Dysfunction* / epidemiology
Cognitive Dysfunction* / etiology
Humans
Parkinson Disease* / complications
Parkinson Disease* / diagnosis
Parkinson Disease* / epidemiology
REM Sleep Behavior Disorder* / diagnosis
REM Sleep Behavior Disorder* / epidemiology
REM Sleep Behavior Disorder* / etiology
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding