Putative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior

Neuron. 2023 Jun 21;111(12):1979-1992.e7. doi: 10.1016/j.neuron.2023.03.023. Epub 2023 Apr 11.

Abstract

In the reach and saccade regions of the posterior parietal cortex (PPC), multiregional communication depends on the timing of neuronal activity with respect to beta-frequency (10-30 Hz) local field potential (LFP) activity, termed dual coherence. Neural coherence is believed to reflect neural excitability, whereby spiking tends to occur at a particular phase of LFP activity, but the mechanisms of multiregional dual coherence remain unknown. Here, we investigate dual coherence in the PPC of non-human primates performing eye-hand movements. We computationally model dual coherence in terms of multiregional neural excitability and show that one latent component, a multiregional mode, reflects shared excitability across distributed PPC populations. Analyzing the power in the multiregional mode with respect to different putative cell types reveals significant modulations with the spiking of putative pyramidal neurons and not inhibitory interneurons. These results suggest a specific role for pyramidal neurons in dual coherence supporting multiregional communication in PPC.

Keywords: arm movements; coordinated behavior; eye movements; multiregional communication; posterior parietal; putative cell type; spike waveform.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Neurons* / physiology
  • Parietal Lobe* / physiology
  • Pyramidal Cells / physiology