Histologically Confirmed Testicular Metastasis Revealed by [89Zr]Zr-PSMA-617 PET/CT in a Patient with Biochemical Recurrence of Prostate Cancer and Negative Conventional PSMA PET/CT Imaging

Florian Rosar; Caroline Burgard; Johannes Linxweiler; Mathias Wagner; Samer Ezziddin

doi:10.3390/diagnostics13071352

Histologically Confirmed Testicular Metastasis Revealed by [⁸⁹Zr]Zr-PSMA-617 PET/CT in a Patient with Biochemical Recurrence of Prostate Cancer and Negative Conventional PSMA PET/CT Imaging

Diagnostics (Basel). 2023 Apr 5;13(7):1352. doi: 10.3390/diagnostics13071352.

Authors

Florian Rosar¹, Caroline Burgard¹, Johannes Linxweiler², Mathias Wagner³, Samer Ezziddin¹

Affiliations

¹ Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany.
² Department of Urology, Saarland University, 66421 Homburg, Germany.
³ Department of Pathology, Saarland University, 66421 Homburg, Germany.

Abstract

We present an interesting image of a testicular metastasis from prostate cancer revealed by [⁸⁹Zr]Zr-PSMA-617 PET/CT imaging in a 70-year-old man with biochemical recurrence and negative conventional [⁶⁸Ga]Ga-PSMA-11 PET/CT imaging. This case should encourage the consideration of [⁸⁹Zr]Zr-PSMA-617 PET/CT if conventional PSMA PET/CT imaging had failed to localize biochemical recurrence, and may remind colleagues of this rare but potential metastatic localization in this setting.

Keywords: PET/CT; PSMA; biochemical recurrence; prostate cancer; zirconium.

Grants and funding

This research received no external funding.