A Case of Multiple Myeloma-Associated Systemic Amyloidosis with Multiple Skin Manifestations as the First Symptom

Shunyu Yao; Suxia Wang; Runxi Yi; Liwei Ran; Cang Zhang

doi:10.2147/CCID.S405330

A Case of Multiple Myeloma-Associated Systemic Amyloidosis with Multiple Skin Manifestations as the First Symptom

Clin Cosmet Investig Dermatol. 2023 Apr 9:16:987-993. doi: 10.2147/CCID.S405330. eCollection 2023.

Authors

Shunyu Yao^{1

2}, Suxia Wang^#³, Runxi Yi^#^{1

4}, Liwei Ran⁵, Cang Zhang²

Affiliations

¹ Chinese Traditional Medicine, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
² Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People's Republic of China.
³ Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, People's Republic of China.
⁴ Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People's Republic of China.
⁵ Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.

^# Contributed equally.

Abstract

An 81-year-old woman presented with purpura, petechiae, ecchymoses, flesh or brown-colored waxy, smooth, papules, warty plaque, nail dystrophy and palmodigital erythematous swelling for more than 6 years. She was diagnosed as multiple myeloma-associated systemic amyloidosis after skin subcutaneous histopathological examinations and relevant examinations such as blood and bone marrow. Systemic amyloidosis is closely related with multiple myeloma (MM). Multiple and pleomorphic skin lesions are not usual among patients with multiple myeloma or systemic amyloidosis.

Keywords: monoclonal immunoglobulin; multiple myeloma; primary systemic amyloidosis.

Publication types

Case Reports