In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.
Keywords: ADCC; Omicron; antibody-dependent cell-mediated cytotoxicity; durability; hybrid immunity.
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.