Converging on a Cure: The Roads to Predictive Immunotherapy

Genevieve L Stein-O'Brien; Dung T Le; Elizabeth M Jaffee; Elana J Fertig; Neeha Zaidi

doi:10.1158/2159-8290.CD-23-0277

Converging on a Cure: The Roads to Predictive Immunotherapy

Cancer Discov. 2023 May 4;13(5):1053-1057. doi: 10.1158/2159-8290.CD-23-0277.

Authors

Genevieve L Stein-O'Brien^{1

2

3

4

5}, Dung T Le^{1

3

6}, Elizabeth M Jaffee^{1

3

6}, Elana J Fertig^{1

2

6

7

8}, Neeha Zaidi^{1

3

6}

Affiliations

¹ Johns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
⁴ Kavli Neurodiscovery Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁵ Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland.
⁶ Johns Hopkins Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁷ Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
⁸ Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland.

Abstract

Convergence science teams integrating clinical, biological, engineering, and computational expertise are inventing new forecast systems to monitor and predict evolutionary changes in tumor and immune interactions during early cancer progression and therapeutic response. The resulting methods should inform a new predictive medicine paradigm to select adaptive immunotherapeutic regimens personalized to patients' tumors at a given time during their cancer progression for durable patient response.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Resistance
Humans
Immunotherapy* / methods
Immunotherapy* / trends
Neoplasms* / genetics
Neoplasms* / immunology
Neoplasms* / therapy
Precision Medicine* / methods
Precision Medicine* / trends
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding