An S-like curve relationship between systemic inflammation response index (SIRI) and respiratory failure in GBS patients

Neurol Sci. 2023 Sep;44(9):3279-3285. doi: 10.1007/s10072-023-06784-y. Epub 2023 Apr 20.

Abstract

Background: Our study examined the association between the initial systemic inflammation response index (SIRI) and respiratory failure in patients with Guillain-Barré syndrome (GBS).

Methods: The weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piece linear regression model were utilized for data analysis.

Results: Among the 443 GBS patients, 75 (6.9%) had experienced respiratory failure. According to logistic regression models, there existed no consistent linear relationship between respiratory failure and SIRI in model 1 (OR = 1.2, p < 0.001), model 2 (OR = 1.2, p < 0.001), and model 3 (OR = 1.3, p = 0.017). However, smooth curve fittings found an S-like curve relationship between SIRI and respiratory failure. Furthermore, when SIRI was < 6.4, there existed a positive correlation between SIRI and respiratory failure in model 1 (OR = 1.5, 95% CI = (1.3, 1.8), p < 0.0001), higher correlation in model 2 (OR = 1.6, 95% CI = (1.3, 1.8), p < 0.0001), and highest correlation in model 3 (OR = 1.6, 95% CI = (1.3, 2.5), p < 0.0001).

Conclusions: SIRI can be used as a predictor of respiratory failure in GBS, and an S-like relationship exists between SIRI and respiratory failure at an infliction point of 6.4. When the SIRI was less than 6.4 and increased, SIRI was associated with a higher occurrence of respiratory failure. The risk of respiratory failure was no longer increased when the SIRI was over 6.4.

Keywords: Guillain-Barré syndrome (GBS); Predictor; Respiratory failure; SIRI.

MeSH terms

  • Guillain-Barre Syndrome* / complications
  • Humans
  • Inflammation / complications
  • Logistic Models
  • Respiratory Insufficiency* / etiology
  • Retrospective Studies