Amyloid transthyretin cardiac amyloidosis with different manifestations, test findings and types

BMJ Case Rep. 2023 Apr 20;16(4):e250972. doi: 10.1136/bcr-2022-250972.

Abstract

Amyloid transthyretin amyloidosis usually presents with cardiac amyloidosis manifestations, most commonly with a heart failure syndrome. The history and physical examination offer clues of other cardiac and extracardiac manifestations. Taking a detailed history is essential in elucidating pertinent family and medical history that may increase suspicion for amyloidosis. Further, certain findings on electrocardiogram and imaging should raise suspicion and trigger further workup that can confirm the diagnosis, since treatment is evolving.

Keywords: Cardiovascular system; Heart failure.

Publication types

  • Case Reports

MeSH terms

  • Amyloid Neuropathies, Familial* / complications
  • Amyloid Neuropathies, Familial* / diagnosis
  • Amyloid Neuropathies, Familial* / therapy
  • Cardiomyopathies* / diagnosis
  • Cardiomyopathies* / therapy
  • Diagnostic Imaging
  • Electrocardiography
  • Heart Failure* / diagnosis
  • Heart Failure* / etiology
  • Humans
  • Prealbumin

Substances

  • Prealbumin