Total Synthesis of (+)-Aberrarone

J Am Chem Soc. 2023 May 3;145(17):9459-9463. doi: 10.1021/jacs.3c02511. Epub 2023 Apr 21.

Abstract

The structurally intriguing diterpene (+)-aberrarone has been assembled in only 12 steps from the commercially available (S,S)-carveol without protecting group manipulations. This concise synthesis features a Cu-catalyzed asymmetric hydroboration to generate the chiral methyl group, a Ni-catalyzed reductive coupling to link two fragments, and a Mn-mediated radical cascade cyclization to construct the triquinane system.