The roles of the SOX2 protein in the development of esophagus and esophageal squamous cell carcinoma, and pharmacological target for therapy

Biomed Pharmacother. 2023 Jul:163:114764. doi: 10.1016/j.biopha.2023.114764. Epub 2023 Apr 24.

Abstract

SOX2 is a transcription factor belonging to the SOX gene family, whose activity has been associated with the maintenance of the stemness and self-renewal of embryonic stem cells (ESCs), as well as the induction of differentiated cells into induced pluripotent stem cells (iPSCs). Moreover, accumulating studies have shown that SOX2 is amplified in various cancers, notably in esophageal squamous cell carcinoma (ESCC). In addition, SOX2 expression is linked to multiple malignant processes, including proliferation, migration, invasion, and drug resistance. Taken together, targeting SOX2 might shed light on novel approaches for cancer therapy. In this review, we aim to summarize the current knowledge regarding SOX2 in the development of esophagus and ESCC. We also highlight several therapeutic strategies for targeting SOX2 in different cancer types, which can provide new tools to treat cancers possessing abnormal levels of SOX2 protein.

Keywords: Cancer therapy; Esophageal squamous cell carcinoma; SOX2; Tumorigenesis.

Publication types

  • Review

MeSH terms

  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Proliferation
  • Esophageal Neoplasms* / genetics
  • Esophageal Squamous Cell Carcinoma* / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • SOXB1 Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Transcription Factors
  • SOXB1 Transcription Factors
  • SOX2 protein, human