Autophagy Inhibition as a Potential Therapeutic Strategy for Breast Cancer with Mitochondrial Translation Defect Caused by CBFB-Deficiency

Autophagy. 2023 Nov;19(11):3026-3028. doi: 10.1080/15548627.2023.2208481. Epub 2023 May 5.

Abstract

AMPK, AMP-activated protein kinase; BioID, biotinylation identification; CBFB, core-binding factor subunit beta; HCQ, hydroxychloroquine; HNRNPK, heterogeneous nuclear ribonucleoprotein K; PDX, patient-derived xenograft; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; TUFM, Tu translation elongation factor, mitochondrial; ETC, electron transport chain.

Keywords: Autophagy; CBFB; PIK3CA; autophagy in cancer; autophagy targeting; breast cancer; mitochondria; mitochondrial translation; mitophagy.

Publication types

  • Research Support, N.I.H., Intramural
  • Comment

MeSH terms

  • Autophagy*
  • Breast Neoplasms* / drug therapy
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / metabolism
  • Core Binding Factor beta Subunit / metabolism
  • Female
  • Humans
  • Mitochondria / metabolism

Substances

  • CBFB protein, human
  • Core Binding Factor beta Subunit