CAND1 orchestrates CRLs through rock and roll

Cell. 2023 Apr 27;186(9):1817-1818. doi: 10.1016/j.cell.2023.04.001.

Abstract

Proper regulation of protein degradation is essential for cell physiology. In the current issue of Cell, Baek et al. elucidated how a large class of ubiquitin ligase, known as CRL, is assembled and disassembled through a key regulator, CAND1.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cullin Proteins / metabolism
  • Proteolysis
  • Transcription Factors* / metabolism
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases* / metabolism

Substances

  • CAND1 protein, human
  • Cullin Proteins
  • Transcription Factors
  • Ubiquitin
  • Ubiquitin-Protein Ligases