Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases

Affiliations

• ¹ Broad Institute of the Massachusetts Institute of Technology and Harvard University, The Klarman Cell Observatory, Cambridge, MA, USA. [email protected].
• ² Department of Epidemiology and Public Health, University College London, London, UK. [email protected].
• ³ Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland. [email protected].
• ⁴ Broad Institute of the Massachusetts Institute of Technology and Harvard University, The Klarman Cell Observatory, Cambridge, MA, USA.
• ⁵ Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
• ⁶ Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland.
• ⁷ Department of Epidemiology and Public Health, University College London, London, UK.
• ⁸ Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.
• ⁹ Research & Development, Biogen Inc., Cambridge, MA, USA.
• ¹⁰ Division of Psychiatry, University College London, London, UK.
• ¹¹ Camden and Islington NHS Foundation Trust, London, UK.
• ¹² Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.
• ¹³ Boston University School of Public Health, Boston, MA, USA.
• ¹⁴ New York University Grossman School of Medicine, New York, NY, USA.
• ¹⁵ Boston University School of Medicine, Boston, MA, USA.
• ¹⁶ Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• ¹⁷ Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• ¹⁸ Institute of Cardiovascular Science, University College London, London, UK.
• ¹⁹ University College London, British Heart Foundation Research Accelerator, London, UK.
• ²⁰ Health Data Research UK, London, UK.