Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations

BJOG. 2023 Nov;130(12):1437-1450. doi: 10.1111/1471-0528.17511. Epub 2023 May 2.

Abstract

Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.

Keywords: BRCA1; BRCA2; early menopause; hormone replacement therapy; hot flushes; ovarian cancer; risk-reducing salpingo-oophorectomy; sexual function; surgical menopause.

Publication types

  • Review

MeSH terms

  • Adult
  • Consensus
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / prevention & control
  • Ovarian Neoplasms* / surgery
  • Ovariectomy
  • Premenopause
  • Quality of Life
  • Salpingo-oophorectomy*