Cost-effectiveness of selective internal radiation therapy with Y-90 resin microspheres for intermediate- and advanced-stage hepatocellular carcinoma in Brazil

J Med Econ. 2023 Jan-Dec;26(1):731-741. doi: 10.1080/13696998.2023.2210475.

Abstract

Aims: Hepatocellular carcinoma (HCC) is a severe condition with poor prognosis that places a significant burden on patients, caregivers, and healthcare systems. Selective internal radiation therapy (SIRT) is a treatment available to patients with HCC which addresses some of the limitations of alternative treatment options. A cost-effectiveness analysis was undertaken into the use of SIRT using Y-90 resin microspheres for the treatment of unresectable intermediate- and late-stage HCC in Brazil.

Materials and methods: A partitioned-survival model was developed, including a tunnel state for patients downstaged to receive treatments with curative intent. Sorafenib was the selected comparator, a common systemic treatment in Brazil and for which comparative evidence exists. Clinical data were extracted from published sources of pivotal trials, and effectiveness was measured in quality-adjusted life-years (QALYs) and life-years (LYs). The analysis was conducted from the Brazilian private payer perspective and a lifetime horizon was implemented. Comprehensive sensitivity analyses were conducted.

Results: LYs and QALYs were higher for SIRT with Y-90 resin microspheres versus sorafenib (0.27 and 0.20 incremental LYs and QALYs, respectively) and costs were slightly higher for SIRT (R$15,864). The base case incremental cost-effectiveness ratio (ICER) was R$77,602 per QALY. The ICER was mostly influenced by parameters defining the sorafenib overall survival curve and SIRT had a 73% probability of being cost-effective at a willingness-to-pay threshold of R$135,761 per QALY (3-times the per-capita gross domestic product in Brazil). Overall, sensitivity analyses confirmed the robustness of the results indicating that SIRT with Y-90 resin microspheres is cost-effective compared with sorafenib.

Limitations: A rapidly evolving treatment landscape in Brazil and worldwide, and the lack of local data for some variables were the main limitations.

Conclusions: SIRT with Y-90 resin microspheres is a cost-effective option compared with sorafenib in Brazil.

Keywords: Brazil; C; C5; C51; D; D6; D61; Hepatocellular carcinoma; Y-90 resin microspheres; cost-effectiveness; selective internal radiation therapy; sorafenib; transarterial radioembolization.

MeSH terms

  • Brazil
  • Carcinoma, Hepatocellular* / drug therapy
  • Cost-Benefit Analysis
  • Humans
  • Liver Neoplasms* / drug therapy
  • Microspheres
  • Sorafenib / therapeutic use
  • Yttrium Radioisotopes

Substances

  • Sorafenib
  • Yttrium-90
  • Yttrium Radioisotopes