A review of recent developments of metal-organic frameworks as combined biomedical platforms over the past decade

Mojtaba Moharramnejad; Rahime Eshaghi Malekshah; Ali Ehsani; Sajjad Gharanli; Mehrnaz Shahi; Saeed Alvani Alvan; Zahra Salariyeh; Maryam Nasr Azadani; Jebiti Haribabu; Zahra Salmanivand Basmenj; Ali Khaleghian; Hossein Saremi; Zahra Hassani; Elham Momeni

doi:10.1016/j.cis.2023.102908

A review of recent developments of metal-organic frameworks as combined biomedical platforms over the past decade

Adv Colloid Interface Sci. 2023 Jun:316:102908. doi: 10.1016/j.cis.2023.102908. Epub 2023 Apr 25.

Authors

Affiliations

¹ Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran; Young Researcher and Elite Group, University of Qom, Qom, Iran.
² Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran; Department of Chemistry, Semnan University, Semnan, Iran. Electronic address: [email protected].
³ Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran. Electronic address: [email protected].
⁴ Department of Chemical Engineering, Faculty of Engineering, Qom University, Qom, Iran.
⁵ Department of Chemistry, Semnan University, Semnan, Iran.
⁶ Bachelor of Chemical Engineering, Azad Varamin University, Peshwa branch, Iran.
⁷ School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
⁸ Facultad de Medicina, Universidad de Atacama, Los Carreras 1579, 1532502 Copiapo, Chile.
⁹ Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Iran.
¹⁰ Biochemistry Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
¹¹ Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Iran.
¹² Department of New Materials, Institute of Science, High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 7631818356, Iran.

PMID: 37148581
DOI: 10.1016/j.cis.2023.102908

Abstract

Metal-organic frameworks (MOFs), also called porous coordination polymers, represent a class of crystalline porous materials made up of organic ligands and metal ions/metal clusters. Herein, an overview of the preparation of different metal-organic frameworks and the recent advances in MOF-based stimuli-responsive drug delivery systems (DDSs) with the drug release mechanisms including pH-, temperature-, ion-, magnetic-, pressure-, adenosine-triphosphate (ATP)-, H₂S-, redox-, responsive, and photoresponsive MOF were rarely introduced. The combination therapy containing of two or more treatments can be enhanced treatment effectiveness through overcoming limitations of monotherapy. Photothermal therapy (PTT) combined with chemotherapy (CT), chemotherapy in combination with PTT or other combinations were explained to overcome drug resistance and side effects in normal cells as well as enhancing the therapeutic response. Integrated platforms containing of photothermal/drug-delivering functions with magnetic resonance imaging (MRI) properties exhibited great advantages in cancer therapy.

Keywords: Chemotherapy; Combination therapy; Photoacoustic imaging; Photodynamic therapy; Photothermal therapy; The stimuli-responsive drug delivery systems.

Publication types

Review

MeSH terms

Drug Delivery Systems
Metal-Organic Frameworks* / chemistry
Metal-Organic Frameworks* / pharmacology
Metals

Substances

Metal-Organic Frameworks
Metals