Modern Classification and Management of Pediatric B-cell Leukemia and Lymphoma

Alexandra E Kovach; Gordana Raca

doi:10.1016/j.path.2023.01.001

Modern Classification and Management of Pediatric B-cell Leukemia and Lymphoma

Surg Pathol Clin. 2023 Jun;16(2):249-266. doi: 10.1016/j.path.2023.01.001. Epub 2023 Mar 8.

Authors

Alexandra E Kovach¹, Gordana Raca²

Affiliations

¹ Division of Laboratory Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA; Clinical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. Electronic address: [email protected].
² Clinical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA; Division of Genomic Medicine, Department of Pathology and Laboratory Medicine, Center for Personalized Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

PMID: 37149359
DOI: 10.1016/j.path.2023.01.001

Abstract

Although pediatric hematopathology overlaps with that of adults, certain forms of leukemia and lymphoma, and many types of reactive conditions affecting the bone marrow and lymph nodes, are unique to children. As part of this series focused on lymphomas, this article (1) details the novel subtypes of lymphoblastic leukemia seen primarily in children and described since the 2017 World Health Organization classification and (2) discusses unique concepts in pediatric hematopathology, including nomenclature changes and evaluation of surgical margins in selected lymphomas.

Keywords: Anterior mediastinal mass; B-lymphoblastic leukemia; Hematogone hyperplasia; Lymphadenitis; Pediatric leukemia; Pediatric lymphoma; WHO classification.

Publication types

Review

MeSH terms

Adult
Child
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
Lymph Nodes / pathology
Lymphoma* / diagnosis
Lymphoma* / therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*