Cryptosporidium secretome sheds new light on host-parasite interactions

Isabelle Coppens; Honorine D Ward

doi:10.1016/j.pt.2023.04.008

Cryptosporidium secretome sheds new light on host-parasite interactions

Trends Parasitol. 2023 Jul;39(7):499-500. doi: 10.1016/j.pt.2023.04.008. Epub 2023 May 6.

Authors

Isabelle Coppens¹, Honorine D Ward²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
² Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA. Electronic address: [email protected].

PMID: 37150658
DOI: 10.1016/j.pt.2023.04.008

Abstract

Invasive Cryptosporidium sporozoites contain organelles that secrete unique proteins to facilitate invasion and remodeling of the infected cell. By identifying a novel secretory organelle, 'small granules', and defining the global content of all the secretory organelles, Guérin et al. set the stage to uncover molecular determinants of virulence at the host cell interface.

Keywords: Cryptosporidium; host–parasite interactions; proteome; secretory organelles.

MeSH terms

Cryptosporidiosis* / parasitology
Cryptosporidium*
Host-Parasite Interactions
Humans
Organelles / metabolism
Protozoan Proteins / metabolism
Secretome

Substances

Protozoan Proteins