Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae

Xueyou Li; Xiaoxu He; Xiaona Lin; Weihao Li; Jiahao Gao; Ning Zhang; Yusong Guo; Zhongduo Wang; Na Zhao; Bo Zhang; Zhongdian Dong

doi:10.1016/j.aquatox.2023.106551

Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae

Aquat Toxicol. 2023 Jun:259:106551. doi: 10.1016/j.aquatox.2023.106551. Epub 2023 May 7.

Authors

Xueyou Li¹, Xiaoxu He², Xiaona Lin³, Weihao Li³, Jiahao Gao³, Ning Zhang³, Yusong Guo³, Zhongduo Wang³, Na Zhao⁴, Bo Zhang⁵, Zhongdian Dong⁶

Affiliations

¹ Key Laboratory of Aquaculture in the South China Sea for Aquatic Economic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, China; Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, College of Fishery, Guangdong Ocean University, Zhanjiang, China.
² Tianjin Fisheries Research Institute, Tianjin 300200, China.
³ Key Laboratory of Aquaculture in the South China Sea for Aquatic Economic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, China.
⁴ Key Laboratory of Aquaculture in the South China Sea for Aquatic Economic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, China.
⁵ Key Laboratory of Aquaculture in the South China Sea for Aquatic Economic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, China; Tianjin Fisheries Research Institute, Tianjin 300200, China.
⁶ Key Laboratory of Aquaculture in the South China Sea for Aquatic Economic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, China; Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, College of Fishery, Guangdong Ocean University, Zhanjiang, China. Electronic address: [email protected].

PMID: 37156703
DOI: 10.1016/j.aquatox.2023.106551

Abstract

Bisphenols are environmental endocrine disruptors that have detrimental effects on aquatic organisms. Using marine medaka larvae, this study explored the effects of bisphenol compounds [bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF)] on the early growth and development of aquatic organisms. Marine medaka larvae were exposed to bisphenol compounds at concentrations of 0.05, 0.5, and 5 μM for 72 h, and changes in heartbeat rate, behavior, hormone levels, and gene expression were determined. Bisphenols were shown to have a toxic effect on the cardiovascular system of larvae and can cause neurotoxicity and endocrine disruption, such as changes to thyroid-related hormones. Functional enrichment showed that bisphenols mainly affect lipid metabolism and cardiac muscle contraction of larvae, which implied that the main toxic effects of bisphenols on marine medaka larvae targeted the liver and heart. This study provides a theoretical foundation for evaluating the toxicological effects of bisphenols on the early development of aquatic organisms.

Keywords: Oryzias melastigna; bisphenols; lipid metabolism.

MeSH terms

Animals
Benzhydryl Compounds / toxicity
Cardiovascular System*
Larva
Lipid Metabolism
Oryzias*
Thyroid Hormones
Water Pollutants, Chemical* / toxicity

Substances

bisphenol A
Water Pollutants, Chemical
Thyroid Hormones
Benzhydryl Compounds