SnapShot: Eukaryotic ribosome biogenesis I

Ed Hurt; Jingdong Cheng; Jochen Baβler; Janet Iwasa; Roland Beckmann

doi:10.1016/j.cell.2023.04.030

SnapShot: Eukaryotic ribosome biogenesis I

Cell. 2023 May 11;186(10):2282-2282.e1. doi: 10.1016/j.cell.2023.04.030.

Authors

Ed Hurt¹, Jingdong Cheng², Jochen Baβler¹, Janet Iwasa³, Roland Beckmann⁴

Affiliations

¹ Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.
² Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
³ Department of Biochemistry, University of Utah, East, Salt Lake City, UT, USA.
⁴ Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.

PMID: 37172570
DOI: 10.1016/j.cell.2023.04.030

Abstract

Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits unravel the mechanisms of small ribosome synthesis. To view this SnapShot, open or download the PDF.

MeSH terms

Cell Nucleolus / metabolism
Eukaryotic Cells* / metabolism
Humans
Ribosomal Proteins / metabolism
Ribosome Subunits, Small, Eukaryotic / chemistry
Ribosome Subunits, Small, Eukaryotic / metabolism
Ribosomes* / metabolism

Substances

Ribosomal Proteins