Vaccination coverage reinforced by an infectious disease consultation during pretransplant check-up in patients awaiting kidney transplantation: A randomized study

A Calmels; A-E Heng; V Corbin; C Garrouste; C Greze; B Pereira; O Lesens

doi:10.1016/j.idnow.2023.104718

Vaccination coverage reinforced by an infectious disease consultation during pretransplant check-up in patients awaiting kidney transplantation: A randomized study

Infect Dis Now. 2023 Oct;53(7):104718. doi: 10.1016/j.idnow.2023.104718. Epub 2023 May 12.

Authors

A Calmels¹, A-E Heng², V Corbin¹, C Garrouste², C Greze², B Pereira³, O Lesens⁴

Affiliations

¹ Infectious and Tropical Disease Department, Clermont-Ferrand University Hospital Center, Reference Center for Osteoarticular Infections, Regional Reference Center for Tick-Based Vector Diseases, Genome and Environment Microorganisms Laboratory, Clermont Auvergne University, Clermont-Ferrand, France.
² Department of Nephrology, University Hospital, Clermont-Ferrand, France.
³ Clinical Research and Innovation Department, University Hospital, Clermont-Ferrand, France.
⁴ Infectious and Tropical Disease Department, Clermont-Ferrand University Hospital Center, Reference Center for Osteoarticular Infections, Regional Reference Center for Tick-Based Vector Diseases, Genome and Environment Microorganisms Laboratory, Clermont Auvergne University, Clermont-Ferrand, France. Electronic address: [email protected].

PMID: 37178869
DOI: 10.1016/j.idnow.2023.104718

Abstract

Background: Vaccine coverage (VC) in patients awaiting kidney transplantation is insufficient.

Methods: We performed a prospective, single-center, interventional, randomized, open-label study comparing a reinforced group (infectious disease consultation proposed) and a standard group (letter stating vaccine recommendations sent to the nephrologist) of patients in our institution awaiting renal transplantation.

Findings: Out of the 58 eligible patients, 19 declined to participate. Twenty patients were randomized to the standard group and 19 to the reinforced group. Essential VC increased from. 10% to 20% in the standard group and from 15.8% to 52.6% in the reinforced group (p < 0.034). The main obstacles identified were lack of vaccination traceability, refusal of an additional consultation and the journey time between home and hospital.

Conclusion: While introduction of an infectious disease consultation during the pre-transplant check-up significantly improved VC in patients, it is time-consuming and failed to achieve a satisfactory rate of VC.

Keywords: Infectious diseases; Kidney transplantation; Primary prevention; Vaccination.