Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging

Natl Sci Rev. 2023 Mar 9;10(6):nwad067. doi: 10.1093/nsr/nwad067. eCollection 2023 Jun.

Fu-Hui Xiao^{1

2}, Hao-Tian Wang^{1

2

3}, Xiao-Qiong Chen¹, Ming-Xia Ge^{1

2

3}, Dongjing Yan⁴, Xing-Li Yang¹, Li-Qin Yang^{1

2}, Rong Lin⁵, Rong-Hui Guo^{1

2

3}, Wen Zhang⁴, Nelson Leung-Sang Tang^{2

6}, Yonghan He¹, Jumin Zhou⁷, Wang-Wei Cai⁴, Qing-Peng Kong^{1

8

2}

¹ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, China.
² KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, China.
³ Kunming College of Life Science, University of Chinese Academy of Sciences, China.
⁴ Department of Biochemistry and Molecular Biology, Hainan Medical College, China.
⁵ Department of Biology, Hainan Medical College, China.
⁶ Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, China.
⁷ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, China.
⁸ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, China.

No abstract available