Study on the Interaction between Silibinin and Neuraminidase

Curr Pharm Des. 2023;29(16):1266-1273. doi: 10.2174/1381612829666230515165041.

Abstract

Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.

Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.

Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.

Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.

Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.

Keywords: Neuraminidase; Peramivir; Uv-vis spectroscopy; avian influenza virus; drugs; neuraminidase inhibitor; silibinin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents* / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Influenza A virus* / drug effects
  • Neuraminidase* / antagonists & inhibitors
  • Silybin* / pharmacology

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Neuraminidase
  • Silybin