Hexokinases in cancer and other pathologies

Dong Guo; Ying Meng; Xiaoming Jiang; Zhimin Lu

doi:10.1016/j.cellin.2023.100077

Hexokinases in cancer and other pathologies

Cell Insight. 2023 Jan 3;2(1):100077. doi: 10.1016/j.cellin.2023.100077. eCollection 2023 Feb.

Authors

Dong Guo^{1

2}, Ying Meng^{1

2}, Xiaoming Jiang^{1

2}, Zhimin Lu^{1

2}

Affiliations

¹ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
² Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.

Abstract

Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal roles in glucose metabolism through canonical functions of hexokinases as well as in immune response, cell stemness, autophagy, and other cellular activities through noncanonical functions. The aberrant regulation of hexokinases contributes to the development and progression of pathologies, including cancer and immune diseases.

Keywords: Cancer; Glucose metabolism; Glycolysis; Hexokinase; Immune diseases; Protein kinase.

Publication types

Review