Hairy cell leukemia with isolated bone lesions

Key clinical message: ¹⁸F-FDG PET/CT has clinical relevance in HCL at diagnosis and for the follow-up of patients treated, especially in case of atypical presentations such as bone involvements (which are probably underestimated) and poor bone marrow infiltration.

Abstract: Bone lesions are rarely reported in Hairy Cell Leukemia (HCL). We report two BRAF^V600E mutated HCL patients presented bone lesions at foreground, poor bone marrow involvement, and the important role ¹⁸F-FDG PET/CT played in their management. We discuss the crucial role that ¹⁸F-FDG PET/CT could play in HCL routine practice.