Ectopically expressed Airn lncRNA deposits Polycomb with a potency that rivals Xist

bioRxiv [Preprint]. 2023 May 9:2023.05.09.539960. doi: 10.1101/2023.05.09.539960.

Abstract

We report that when expressed at similar levels from an isogenic locus, the Airn lncRNA induces Polycomb deposition with a potency that rivals Xist . However, when subject to the same degree of promoter activation, Xist is more abundant and more potent than Airn . Our data definitively demonstrate that the Airn lncRNA is functional and suggest that Xist achieved extreme potency in part by evolving mechanisms to promote its own abundance.

Publication types

  • Preprint