A multi-omics perspective of CAR T cell therapy

Jingwen Yang; Yamei Chen; Leng Han

doi:10.1002/ctm2.1274

A multi-omics perspective of CAR T cell therapy

Clin Transl Med. 2023 May;13(5):e1274. doi: 10.1002/ctm2.1274.

Authors

Jingwen Yang¹, Yamei Chen¹, Leng Han^{1

2}

Affiliations

¹ Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA.
² Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, Texas, USA.

Abstract

As omics technologies, including genomics, epigenomics, transcriptomics, T cell receptor-repertorie profiling, proteomics, metabolomics and microbiomics, have provided valuable insights into CAR T cell therapy, in our recent review, we discuss these multidimensional profiling technologies in CAR T cell research, and their potential to identify tumor-specific antigens and molecular characteristics associated with anti-tumour effects and toxicities.

Keywords: CART; Omics.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Epigenomics / methods
Genomics / methods
Humans
Immunotherapy, Adoptive
Multiomics*
Neoplasms* / genetics
Neoplasms* / therapy
Proteomics / methods

Abstract

Publication types

MeSH terms

Grants and funding