Pathogenic variants in the alpha-synuclein (SNCA) gene cause familial forms of Parkinson's disease (PD). Here, we describe generation of six isogenic controls from iPS cell lines derived from two PD disease patients carrying the SNCAp.A53T variant. The controls were created using CRISPR/Cas9 technology and are available for use by the PD research community to study A53T-related synucleinopathies.
Published by Elsevier B.V.