Highlighting extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak by routine genomic typing

F Gravey; S Wilson; A Denisenko; C Lehoussel; Marguerite Fines-Guyon; S Le Hello; C Jeanne-Leroyer

doi:10.1016/j.heliyon.2023.e16131

Highlighting extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak by routine genomic typing

Heliyon. 2023 May 15;9(5):e16131. doi: 10.1016/j.heliyon.2023.e16131. eCollection 2023 May.

Authors

F Gravey^{1

2}, S Wilson³, A Denisenko⁴, C Lehoussel¹, Marguerite Fines-Guyon², S Le Hello^{1

2

3}, C Jeanne-Leroyer¹

Affiliations

¹ Univ de Caen Normandie, Univ Rouen Normandie, INSERM DYNAMICURE UMR 1311, CHU Caen, Caen, France.
² CHU Caen, Departement of Microbiology, F-14000, Caen, France.
³ CHU Caen, Departement of Hospital Hygiene and Infection Control, F-14000, Caen, France.
⁴ CHU Caen, Departement of Surgical Intensive Care Unit, F-14000, Caen, France.

Abstract

Whole genome sequencing has become the gold standard for any microbiological investigations. Taking the opportunity to doing it prospectively and routinely allowed to detect undeclared outbreaks. Thanks to that, we investigated and ended a rare epidemic extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST584 strain on two intensive care units over a 4-month period.

Keywords: ESBL; Klebsiella pneumoniae; Outbreak; ST584; Whole genome sequencing.

Publication types

Case Reports