Roles of Krüppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism

Sian E Piret

doi:10.1159/000531336

Roles of Krüppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism

Nephron. 2023;147(12):766-768. doi: 10.1159/000531336. Epub 2023 Jun 1.

Author

Sian E Piret¹

Affiliation

¹ Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

PMID: 37263229
DOI: 10.1159/000531336

Abstract

Members of the Krüppel-like family of transcription factors are widely expressed, including in the kidney. Expression of some KLFs changes in acute kidney injury, and this may be adaptive or maladaptive, and result in effects on various cellular pathways. This mini-review will highlight the roles of KLF6 and KLF15 in control of proximal tubular cell metabolism.

Keywords: Acute kidney injury; Metabolism; Proximal tubule; Transcription factors.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Epithelial Cells / metabolism
Humans
Kidney / metabolism
Kruppel-Like Factor 6 / genetics
Kruppel-Like Factor 6 / metabolism
Kruppel-Like Transcription Factors* / genetics
Kruppel-Like Transcription Factors* / metabolism
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Kruppel-Like Transcription Factors
Transcription Factors
KLF6 protein, human
Kruppel-Like Factor 6
KLF15 protein, human

Grants and funding

R01 DK133238/DK/NIDDK NIH HHS/United States