Tenecteplase

Tenecteplase (TNK) is a single-bolus recombinant fibrinolytic agent used to manage intravascular clots. The drug is in the tissue plasminogen activator (tPA) class of medications. FDA-approved indications include acute ST-elevation myocardial infarction (STEMI). Tenecteplase is the thrombolytic agent of choice for acute myocardial infarction. Tenecteplase is becoming more widely used as a thrombolytic agent despite its off-label use in acute ischemic strokes largely because of its efficacy when compared with the FDA-approved alteplase. This activity explores the indications, contraindications, activity, adverse event profile, toxicities, and monitoring of tenecteplase to assist the interprofessional team in caring for patients who need thrombolytic therapy.