Transformative Materials for Interfacial Drug Delivery

Prachi Desai; Anshuman Dasgupta; Alexandros Marios Sofias; Quim Peña; Robert Göstl; Ioana Slabu; Ulrich Schwaneberg; Thomas Stiehl; Wolfgang Wagner; Stefan Jockenhövel; Julia Stingl; Rafael Kramann; Christian Trautwein; Tim H Brümmendorf; Fabian Kiessling; Andreas Herrmann; Twan Lammers

doi:10.1002/adhm.202301062

Transformative Materials for Interfacial Drug Delivery

Adv Healthc Mater. 2023 Aug;12(20):e2301062. doi: 10.1002/adhm.202301062. Epub 2023 Jun 6.

Authors

Prachi Desai¹, Anshuman Dasgupta¹, Alexandros Marios Sofias^{1

2}, Quim Peña¹, Robert Göstl³, Ioana Slabu⁴, Ulrich Schwaneberg⁵, Thomas Stiehl^{2

6}, Wolfgang Wagner^{2

7

8}, Stefan Jockenhövel⁹, Julia Stingl¹⁰, Rafael Kramann^{11

12}, Christian Trautwein^{2

13}, Tim H Brümmendorf^{2

14}, Fabian Kiessling^{1

2

7}, Andreas Herrmann^{3

15}, Twan Lammers^{1

2

7}

Affiliations

¹ Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074, Aachen, Germany.
² Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD), 52074, Aachen, Germany.
³ DWI - Leibniz Institute for Interactive Materials, 52074, Aachen, Germany.
⁴ Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany.
⁵ Institute of Biotechnology, RWTH Aachen University, 52074, Aachen, Germany.
⁶ Institute for Computational Biomedicine - Disease Modeling, RWTH Aachen University, 52074, Aachen, Germany.
⁷ Helmholtz-Institute for Biomedical Engineering, Medical Faculty of RWTH Aachen University, 52074, Aachen, Germany.
⁸ Institute for Stem Cell Biology, University Hospital of RWTH Aachen, 52074, Aachen, Germany.
⁹ Department of Biohybrid & Medical Textiles (BioTex), AME - Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University, 52074, Aachen, Germany.
¹⁰ Institute of Clinical Pharmacology, University Hospital RWTH Aachen, 52074, Aachen, Germany.
¹¹ Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074, Aachen, Germany.
¹² Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074, Aachen, Germany.
¹³ Department of Medicine III (Gastroenterology, Metabolic diseases and Intensive Care), University Hospital RWTH Aachen, 52074, Aachen, Germany.
¹⁴ Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University Medical School, 52074, Aachen, Germany.
¹⁵ Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany.

Abstract

Drug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on-target therapeutic efficacy and off-target toxic side effects. DDS aid in overcoming biological barriers encountered by drug molecules upon applying them via various routes of administration. They are furthermore increasingly explored for modulating the interface between implanted (bio)medical materials and host tissue. Herein, an overview of the biological barriers and host-material interfaces encountered by DDS upon oral, intravenous, and local administration is provided, and material engineering advances at different time and space scales to exemplify how current and future DDS can contribute to improved disease treatment are highlighted.

Keywords: biomaterials; biomedical engineering; drug delivery; drug targeting; nanomedicines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems*
Pharmaceutical Preparations

Substances

Pharmaceutical Preparations

Grants and funding

864121/ERC_/European Research Council/International