T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Clin Infect Dis. 2023 Oct 13;77(8):1133-1136. doi: 10.1093/cid/ciad356.

Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

Keywords: HIV exposure; Southern Africa; T-SPOT.TB; TB infection; infants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Child
  • HIV
  • HIV Infections* / epidemiology
  • Humans
  • Infant
  • Latent Tuberculosis*
  • Prevalence
  • Tuberculosis* / prevention & control