Effect of live combined Bifidobacterium and Lactobacillus tablets combined with Soave radical operation on postoperative intestinal flora and immune function in children with Hirschsprung disease

Objective: To investigate the effects of live combined Bifidobacterium and Lactobacillus tablets combined with Soave radical operation on postoperative intestinal flora and immune function in children with Hirschsprung disease (HD).

Methods: A total of 126 cases in the Xi'an Children's Hospital from January 2018-December 2021 were retrospective analyzed. Among them, 60 cases treated with Soave radical operation alone were the control group (CG), and the other 66 cases with live combined Bifidobacterium and Lactobacillus tablets and Soave radical operation were set as the observation group (OG). We compared the treatment efficacy, adverse effects, defecation function, and the number of intestinal flora and IgG and IgA levels at the time of admission and after 3 months of treatment between both groups of children.

Results: The efficacy efficiency and excellent defecation function rate were dramatically higher in the OG than in the CG after treatment (P<0.05). The bifidobacteria, lactobacilli and enterococcus faecalis were dramatically higher in the OG than in the CG after treatment (P<0.05), and the E. coli was dramatically lower than in the CG (P<0.05). After treatment, IgA and IgG in the OG were higher than those in the CG (P<0.05), and the incidence of postoperative complications was lower than that in the CG (P<0.05).

Conclusion: Live combined Bifidobacterium and Lactobacillus tablets combined with Soave radical operation can effectively improve intestinal flora dysbiosis and immune function in children with HD. It has a better effect on the ability to defecate and a marked effect on the prevention of complications, which has a high clinical application value.