Thanks for the memories: Low-avidity T cells shine against escape variants

Pirooz Zareie; Nicole L La Gruta

doi:10.1016/j.immuni.2023.05.013

Thanks for the memories: Low-avidity T cells shine against escape variants

Immunity. 2023 Jun 13;56(6):1160-1162. doi: 10.1016/j.immuni.2023.05.013.

Authors

Pirooz Zareie¹, Nicole L La Gruta²

Affiliations

¹ Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
² Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. Electronic address: [email protected].

PMID: 37315530
DOI: 10.1016/j.immuni.2023.05.013

Abstract

T cell responses against foreign antigens are clonally diverse, but the significance of this diversity is unclear. In this issue of Immunity, Straub et al.¹ show that recruitment of low-avidity T cells during primary infection can provide protection against subsequent encounter with escape variants.