Dietary Effects on Monocyte Phenotypes in Subjects With Hypertriglyceridemia and Metabolic Syndrome

Zeqin Lian; Xiao-Yuan Dai Perrard; Antu Kalathookunnel Antony; Xueying Peng; Lu Xu; Jing Ni; Bingqian Zhang; Veronica O'Brien; Anum Saeed; Xiaoming Jia; Aliza Hussain; Bing Yu; Scott I Simon; Frank M Sacks; Ron C Hoogeveen; Christie M Ballantyne; Huaizhu Wu

doi:10.1016/j.jacbts.2023.02.011

Dietary Effects on Monocyte Phenotypes in Subjects With Hypertriglyceridemia and Metabolic Syndrome

JACC Basic Transl Sci. 2023 Apr 26;8(5):460-475. doi: 10.1016/j.jacbts.2023.02.011. eCollection 2023 May.

Authors

Zeqin Lian¹, Xiao-Yuan Dai Perrard¹, Antu Kalathookunnel Antony¹, Xueying Peng^{1

2}, Lu Xu¹, Jing Ni¹, Bingqian Zhang¹, Veronica O'Brien¹, Anum Saeed^{1

3}, Xiaoming Jia^{1

4}, Aliza Hussain^{1

4}, Bing Yu⁵, Scott I Simon⁶, Frank M Sacks⁷, Ron C Hoogeveen¹, Christie M Ballantyne^{1

4}, Huaizhu Wu¹

Affiliations

¹ Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
² Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
³ Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
⁴ Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, Texas, USA.
⁵ Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center, Houston, Texas, USA.
⁶ Department of Biomedical Engineering, University of California, Davis, California, USA.
⁷ Department of Nutrition, Harvard T.H. Chan School of Public Health, and Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

Abstract

In patients with hypertriglyceridemia, a short-term low-saturated fat vs high-saturated fat diet induced lower plasma lipids and improved monocyte phenotypes. These findings highlight the role of diet fat content and composition for monocyte phenotypes and possibly cardiovascular disease risk in these patients. (Effects of Dietary Interventions on Monocytes in Metabolic Syndrome; NCT03591588).

Keywords: ASCVD; high saturated fat diet; hypertriglyceridemia; low saturated fat diet; monocyte.

Associated data

ClinicalTrials.gov/NCT03591588

Abstract

Associated data

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