History of high household pesticide use and Parkinson's disease in Brazil

Dafne Dalledone Moura; Vanderci Borges; Henrique Ballalai Ferraz; Artur F S Schuh; Carlos Roberto de Mello Rieder; Ignacio F Mata; Manuelina Mariana Capellari Macruz Brito; Vitor Tumas; Bruno Lopes Santos-Lobato

doi:10.1016/j.parkreldis.2023.105493

History of high household pesticide use and Parkinson's disease in Brazil

Parkinsonism Relat Disord. 2023 Aug:113:105493. doi: 10.1016/j.parkreldis.2023.105493. Epub 2023 Jun 19.

Authors

Dafne Dalledone Moura¹, Vanderci Borges², Henrique Ballalai Ferraz³, Artur F S Schuh⁴, Carlos Roberto de Mello Rieder⁵, Ignacio F Mata⁶, Manuelina Mariana Capellari Macruz Brito⁷, Vitor Tumas⁸, Bruno Lopes Santos-Lobato⁹

Affiliations

¹ Universidade Federal do Pará, Instituto de Ciências Médicas, Belém, PA, Brazil. Electronic address: [email protected].
² Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo, SP, Brazil. Electronic address: [email protected].
³ Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁴ Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁵ Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address: [email protected].
⁶ Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA. Electronic address: [email protected].
⁷ Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências Comportamentais, Ribeirão Preto, SP, Brazil. Electronic address: [email protected].
⁸ Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências Comportamentais, Ribeirão Preto, SP, Brazil. Electronic address: [email protected].
⁹ Universidade Federal do Pará, Instituto de Ciências Médicas, Belém, PA, Brazil; Serviço de Neurologia, Hospital Ophir Loyola, Belém, PA, Brazil. Electronic address: [email protected].

PMID: 37354828
DOI: 10.1016/j.parkreldis.2023.105493

Abstract

The prevalence of Parkinson's disease (PD) is growing worldwide and household pesticides exposure may be related to this phenomenon. We showed that individuals with high exposure to household pesticides have two times more risk of developing PD. Household pesticide exposure did not impact age at PD onset.

Keywords: Insecticides; Parkinson's disease; Pesticides; Pyrethroids.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Brazil / epidemiology
Environmental Exposure
Humans
Parkinson Disease* / epidemiology
Parkinson Disease* / etiology
Pesticides* / toxicity
Prevalence
Risk Factors

Substances

Pesticides

Grants and funding

R01 NS112499/NS/NINDS NIH HHS/United States