Unreported ent-rosane diterpenes from Croton niveus Jacq. (Euphorbiaceae). Cytotoxic activity and docking studies

Fitoterapia. 2023 Sep:169:105593. doi: 10.1016/j.fitote.2023.105593. Epub 2023 Jun 22.

Abstract

From the bioactive extract of the euphorbiaceous Croton niveus Jacq., three previously unreported ent-rosane diterpenes have been isolated and characterized by conventional methods, in addition to the known compounds lupeol, cajucarinolide and some phytosterols. Two of the ent-rosane diterpenes displayed activity against HCT-15 and PC-3 cancer cell lines, and the results of docking calculations of these compounds with NF-κB and STAT3 receptors agreed with the proposed mode of action of diterpenes against PC-3 cells.

Keywords: Croton niveus; Cytotoxicity; Diterpenes; Docking; Ent-rosanes; Euphorbiaceae.

MeSH terms

  • Antineoplastic Agents* / pharmacology
  • Croton*
  • Diterpenes* / pharmacology
  • Diterpenes, Kaurane*
  • Euphorbiaceae*
  • Molecular Structure

Substances

  • Diterpenes
  • Antineoplastic Agents
  • Diterpenes, Kaurane