Long-term effects of asparaginase-associated pancreatitis

Pediatr Blood Cancer. 2023 Jun 28:e30528. doi: 10.1002/pbc.30528. Online ahead of print.

Abstract

Pancreatitis is a common and severe toxicity that occurs during asparaginase treatment for acute lymphoblastic leukemia, and has received increasing attention during the last decades. However, no consensus regarding follow-up exists. In this commentary, we highlight potential long-term health-related effects following asparaginase-associated pancreatitis, thereby providing clinicians with a framework when following these patients during and after cessation of therapy.

Keywords: ALL; chemotherapy; late effects of cancer treatment; long-term survival; pediatric hematology/oncology.