Abstract
The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.
Copyright: © 2023 O’Callaghan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Humans
-
Mitophagy*
-
Parkinson Disease* / genetics
-
Protein Kinases / genetics
-
Ubiquitin-Protein Ligases / genetics
Substances
-
Protein Kinases
-
Ubiquitin-Protein Ligases
Grants and funding
This perspective article was funded in whole or in part by Aligning Science Across Parkinson’s (grant number ASAP 000478 to JH and HPF, and which funds BOC’s salary) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the authors have applied a CC BY public copyright licence to all Author Accepted Manuscripts arising from this submission. The funders had no role in decision to publish, or preparation of the manuscript.