Synthetic epigenetics-assisted microbial chassis engineering

Irene Komera; Cong Gao; Xiulai Chen; Wei Chen; Liming Liu

doi:10.1016/j.tim.2023.06.001

Synthetic epigenetics-assisted microbial chassis engineering

Trends Microbiol. 2023 Sep;31(9):889-893. doi: 10.1016/j.tim.2023.06.001. Epub 2023 Jul 1.

Authors

Irene Komera¹, Cong Gao¹, Xiulai Chen¹, Wei Chen², Liming Liu³

Affiliations

¹ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China.
² State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
³ State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected].

PMID: 37400289
DOI: 10.1016/j.tim.2023.06.001

Abstract

Microbial chassis engineering is the milestone of efficient biotechnological applications. However, microbial chassis cell engineering is adversely affected by (i) regulatory tool orthogonality, (ii) host metabolic fitness, and (iii) cell population heterogeneity. Herein, we explore how synthetic epigenetics can potentially address these limitations and offer insights into prospects in this field.

Keywords: epigenetics; genetic circuits; genetic engineering; microbial chassis engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biotechnology
Metabolic Engineering*
Synthetic Biology*