A diffuse glioma with oligodendroglial-like cells and extensive calcifications

Brain Pathol. 2024 Jan;34(1):e13187. doi: 10.1111/bpa.13187. Epub 2023 Jul 6.

Abstract

The tumor showed extensive microcalcifications and cells with oval, nuclei and a clear perinuclear halo (A), positive immunostaining for OLIG-2 (B), GFAP (C), and CD34 (D), and intermingled Neu-N-positive neurons (E). FISH revealed multiple signals for the centromere of chromosome 7 (gains) (green probe) and the EGFR locus (red probe) (F, left), and a single signal for the centromere of chromosome 10 (loss) (F, right).

Keywords: FGFR3::TACC3; PLNTY; glioblastoma; glioma; pTERT.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / pathology
  • Calcinosis*
  • Glioma* / genetics
  • Glioma* / pathology
  • Humans
  • Microtubule-Associated Proteins / genetics
  • Oligodendroglia / pathology

Substances

  • Microtubule-Associated Proteins