Expert consensus on the integrated diagnosis of idiopathic multicentric Castleman disease

Rev Esp Patol. 2023 Jul-Sep;56(3):158-167. doi: 10.1016/j.patol.2022.12.003. Epub 2023 Feb 9.

Abstract

Idiopathic multicentric Castleman disease (iMCD) is rare. The differential diagnosis includes inflammatory, autoimmune and neoplastic disease. The identification of the histopathological features of Castleman disease in the lymph node is the main diagnostic criterion. Fifty-three experts from three medical societies (SEMI, SEHH and SEAP) have created a multi-disciplinary consensus document in order to standardise the diagnosis of Castleman disease. Using the Delphi method, specific recommendations for the initial clinical, laboratory and imaging studies have been made for an integrated diagnosis of iMCD as well as for the best way to obtain samples for histopathological confirmation, correct laboratory procedure and interpretation and reporting of results.

Keywords: Delphi technique; Diagnosis; Diagnóstico; Diagnóstico diferencial; Differential diagnosis; Enfermedad de Castleman multicéntrica idiopática; Idiopathic multicentric Castleman disease; Interleucina-6; Interleukin-6; Metodología Delphi.

Publication types

  • Review

MeSH terms

  • Castleman Disease* / diagnosis
  • Consensus
  • Diagnosis, Differential
  • Humans

Supplementary concepts

  • Multi-centric Castleman's Disease