Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders

Hui Luo; Qibin Jiao; Chuanbin Shen; Chenyi Shao; Jinyan Xie; Yue Chen; Xinglin Feng; Xingwei Zhang

doi:10.3389/fendo.2023.1123769

Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders

Front Endocrinol (Lausanne). 2023 Jun 29:14:1123769. doi: 10.3389/fendo.2023.1123769. eCollection 2023.

Authors

Hui Luo¹, Qibin Jiao¹, Chuanbin Shen¹, Chenyi Shao¹, Jinyan Xie¹, Yue Chen¹, Xinglin Feng¹, Xingwei Zhang¹

Affiliation

¹ Department of Clinical Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China.

Abstract

Misfolded proteins retained in the endoplasmic reticulum cause many human diseases. ER-associated degradation (ERAD) is one of the protein quality and quantity control system located at ER, which is responsible for translocating the misfolded proteins or properly folded but excess proteins out of the ER for proteasomal degradation. Recent studies have revealed that mice with ERAD deficiency in specific cell types exhibit impaired metabolism homeostasis and metabolic diseases. Here, we highlight the ERAD physiological functions in metabolic disorders in a substrate-dependent and cell type-specific manner.

Keywords: ERAD; metabolic disorders; proteasomal degradation; quality control; quantity control.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Endoplasmic Reticulum-Associated Degradation*
Humans
Metabolic Diseases*
Mice
Proteins

Substances

Proteins

Grants and funding

This work was supported by grants from National Natural Science Foundation of China (No. 31900933), Natural Science Foundation of Zhejiang Province (LY21C050003).