Case report: Treatment-resistant schizophrenia with auto-aggressive compulsive behavior-Successful management with cariprazine

Lubova Renemane; Elmars Rancans

doi:10.3389/fpsyt.2023.1209077

Case report: Treatment-resistant schizophrenia with auto-aggressive compulsive behavior-Successful management with cariprazine

Front Psychiatry. 2023 Jun 29:14:1209077. doi: 10.3389/fpsyt.2023.1209077. eCollection 2023.

Authors

Lubova Renemane^{1

2}, Elmars Rancans^{1

2}

Affiliations

¹ Riga Stradins University, Department of Psychiatry and Narcology, Riga, Latvia.
² Riga Centre of Psychiatry and Addiction Disorders, Riga, Latvia.

Abstract

The present case report describes a patient with treatment-resistant schizophrenia and auto-aggressive compulsive behavior who was effectively treated with a third-generation antipsychotic medication, cariprazine. The diagnosis was made 12 years ago, and the patient has been hospitalized 14 times and undergone various antipsychotic treatments. Despite receiving both inpatient and outpatient care, the patient's response to treatment has been only partial, and he has been classified as a treatment-resistant case. Therefore, the patient was switched to cariprazine, which led to significant improvements in both positive and negative symptoms, as well as the complete reduction of auto-aggressive compulsive behavior. These improvements contributed to the patient's overall social functioning and the achievement of remission, while also avoiding polypharmacy and eliminating the metabolic side effects associated with previous treatments.

Keywords: aggressive compulsive behavior; antipsychotics; cariprazine; treatment of schizophrenia; treatment-resistant schizophrenia.

Publication types

Case Reports

Grants and funding

Gedeon Richter covered the article submission fee. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.