Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions

Org Biomol Chem. 2023 Aug 2;21(30):6115-6119. doi: 10.1039/d3ob00859b.

Abstract

The synthesis of difluoromethyl-containing compounds exploiting the deoxofluorination reaction of aromatic aldehydes using XtalFluor-E is described. This transformation occurs at room temperature under highly concentrated conditions, i.e., with no added solvent. A wide range of difluoromethyl-containing compounds was obtained in 21 to 87% isolated yields.