Cervical PEComa: Challenges in diagnosis and prognosis of a rare neoplasm

Sarah J Mah; Lien Hoang; Shaina Lee; Sarah Finlayson; Mark S Carey

doi:10.1016/j.gore.2023.101238

Cervical PEComa: Challenges in diagnosis and prognosis of a rare neoplasm

Gynecol Oncol Rep. 2023 Jul 7:48:101238. doi: 10.1016/j.gore.2023.101238. eCollection 2023 Aug.

Authors

Sarah J Mah¹, Lien Hoang², Shaina Lee³, Sarah Finlayson⁴, Mark S Carey⁴

Affiliations

¹ Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada.
² Department of Anatomical Pathology, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada.
³ Department of Gynecology, University of Saskatchewan, Regina, SK, Canada.
⁴ Department of Obstetrics and Gynecology, University of British Columbia, BC Cancer Agency and Vancouver General Hospital, Vancouver, BC, Canada.

Abstract

•Cervical PEComas are rare neoplasms which present a diagnostic challenge.•Large tumour size is an important clinical prognosticator in cervical PEComa.•All reported cases of cervical PEComa classified as benign by Folpe criteria behaved in benign fashion clinically.•Tumours ≤ 4 cm may be assessed with cone biopsy, and simple hysterectomy considered if no adverse pathologic features.•Molecular characterization and linkage with coordinated rare tumour registries may identify novel treatments.

Keywords: Cervical cancer; Outcomes; Pathologic classification; Perivascular epithelioid cell neoplasms (PEComa); Prognostication; Rare tumours.

Publication types

Case Reports