C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke

Olegi N Kukaliia; Sergei V Ageev; Andrey V Petrov; Olga V Kirik; Dmitrii E Korzhevskii; Anatolii A Meshcheriakov; Anastasia A Jakovleva; Liudmila S Poliakova; Tatiana A Novikova; Maria E Kolpakova; Timur D Vlasov; Oleg E Molchanov; Dmitriy N Maistrenko; Igor V Murin; Vladimir V Sharoyko; Konstantin N Semenov

doi:10.1016/j.nano.2023.102698

C₆₀ adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke

Nanomedicine. 2023 Sep:53:102698. doi: 10.1016/j.nano.2023.102698. Epub 2023 Jul 26.

Authors

Olegi N Kukaliia¹, Sergei V Ageev², Andrey V Petrov³, Olga V Kirik⁴, Dmitrii E Korzhevskii⁴, Anatolii A Meshcheriakov¹, Anastasia A Jakovleva¹, Liudmila S Poliakova¹, Tatiana A Novikova¹, Maria E Kolpakova¹, Timur D Vlasov¹, Oleg E Molchanov⁵, Dmitriy N Maistrenko⁵, Igor V Murin³, Vladimir V Sharoyko⁶, Konstantin N Semenov⁷

Affiliations

¹ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia.
² Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
³ Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
⁴ Institute of Experimental Medicine, 12 Akademika Pavlova Str., Saint Petersburg, 197022, Russia.
⁵ A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia.
⁶ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: [email protected].
⁷ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: [email protected].

PMID: 37507062
DOI: 10.1016/j.nano.2023.102698

Abstract

The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C₆₀-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C₆₀-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C₆₀-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.

Keywords: Antioxidant activity; Fullerene adduct; Haemocompatibility; Histology; Ischemia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / pharmacology
Antioxidants / therapeutic use
Arginine / therapeutic use
Fullerenes* / chemistry
Fullerenes* / pharmacology
Fullerenes* / therapeutic use
Humans
Ischemia
Ischemic Stroke*
Nanostructures*
Stroke* / drug therapy
Water

Substances

Antioxidants
Fullerenes
Water
Arginine