Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

Ping Ren; Yingxia Hu; Lei Peng; Luojia Yang; Kazushi Suzuki; Zhenhao Fang; Meizhu Bai; Liqun Zhou; Yanzhi Feng; Yongji Zou; Yong Xiong; Sidi Chen

doi:10.1038/s41392-023-01509-1

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

Signal Transduct Target Ther. 2023 Jul 31;8(1):281. doi: 10.1038/s41392-023-01509-1.

Authors

Ping Ren^#^{1

2}, Yingxia Hu^#³, Lei Peng^#^{1

2}, Luojia Yang^{1

2}, Kazushi Suzuki^{1

2}, Zhenhao Fang^{1

2}, Meizhu Bai^{1

2}, Liqun Zhou^{1

2}, Yanzhi Feng^{1

2}, Yongji Zou^{1

2}, Yong Xiong^#⁴, Sidi Chen^#^{5

6}

Affiliations

¹ Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
² System Biology Institute, Yale University, West Haven, CT, USA.
³ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
⁴ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. [email protected].
⁵ Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. [email protected].
⁶ System Biology Institute, Yale University, West Haven, CT, USA. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antibodies, Bispecific* / therapeutic use
COVID-19*
Cryoelectron Microscopy
Humans
SARS-CoV-2

Substances

Antibodies, Bispecific

Grants and funding

R01 AI163395/AI/NIAID NIH HHS/United States