Variations in S100A8/ A12 Gene Expression Are Associated with the Efficacy of Nintedanib and Acute Exacerbation Development in Idiopathic Pulmonary Fibrosis Patients

Am J Respir Cell Mol Biol. 2023 Aug;69(2):242-246. doi: 10.1165/rcmb.2023-0054LE.

Authors

Naoki Arai^{1

2}, Masayuki Nakajima¹, Masashi Matsuyama¹, Sosuke Matsumura¹, Kai Yazaki¹, Chio Sakai¹, Mizu Nonaka^{1

2}, Hidetoshi Yanai³, Takeshi Numata³, Yusuke Yamamoto⁴, Yoshibumi Akatsu⁴, Hiroaki Iijima⁵, Yuko Morishima¹, Yosuke Matsuno¹, Takeo Endo³, Masafumi Muratani¹, Yukio Ishii², Takefumi Saito², Nobuyuki Hizawa¹

Affiliations

¹ University of Tsukuba Ibaraki, Japan.
² National Hospital Organization Ibaraki Higashi National Hospital Ibaraki, Japan.
³ National Hospital Organization Mito Medical Center Ibaraki, Japan.
⁴ Hitachi General Hospital Ibaraki, Japan.
⁵ Tsukuba Medical Centre Hospital Tsukuba, Japan.

PMID: 37526393
DOI: 10.1165/rcmb.2023-0054LE

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Gene Expression
Humans
Idiopathic Pulmonary Fibrosis* / drug therapy
Idiopathic Pulmonary Fibrosis* / genetics
Idiopathic Pulmonary Fibrosis* / metabolism
Indoles / pharmacology
Indoles / therapeutic use
Treatment Outcome

Substances

nintedanib
Indoles